Lorazepam is a highly effective drug of a benzodiazepine group which has all the five intrinsic properties of these groups. It is available as a conventional, sublingual tablet. An effort has been made to formulate it as an orodispersible tablet by using direct compression and sublimation method. Crospovidone, croscarmellose sodium and sodium starch glycolate are used as a superdisintegrant, ammonium bicarbonate used as a subliming agent. The prepared tablets were evaluated for both pre and post compression parameter including Carr’s index, angle of repose, Hausner ratio, Hardness, Friability, Wetting time, In vitro disintegration time, Water absorption ratio and In vitro drug release. All the formulas showed an acceptable flow character. All the prepared tablets exhibited a good mechanical strength except tablets containing 12% crospovidone and 10% ammonium bicarbonate which has a high percentage of friability. Crospovidone showed the shortest disintegration time among other superdisintegrants. Moreover the addition of microcrystalline cellulose (Avicel PH102) in a suitable concentration to the formula containing crospovidone will decrease the disintegration time. Formula containing 12% crospovidone and 5% microcrystalline cellulose showed a lowest disintegration time (26.66 sec.), a good drug release profile in which the time required for 80% of the drug to be released (t80%) and percent drug dissolved in 2 min (D2min) were 1.3 min and 89.66% respectively, therefore it is selected as the best formula.
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